Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing

Extracellular ATP binds to and signals through P2X7 receptors (P2X7Rs) to modulate immune function in both inflammasome-dependent and -independent manners. In this study, P2X7(−/−) mice, the pharmacological agonists ATP-magnesium salt (Mg-ATP; 100 mg/kg, EC(50) ≈ 1.32 mM) and benzoylbenzoyl-ATP (Bz-...

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Dades bibliogràfiques
Publicat a:FASEB J
Autors principals: Csóka, Balázs, Németh, Zoltán H., Törő, Gábor, Idzko, Marco, Zech, Andreas, Koscsó, Balázs, Spolarics, Zoltán, Antonioli, Luca, Cseri, Karolina, Erdélyi, Katalin, Pacher, Pál, Haskó, György
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2015
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550379/
https://ncbi.nlm.nih.gov/pubmed/26060214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-272450
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