Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing

Extracellular ATP binds to and signals through P2X7 receptors (P2X7Rs) to modulate immune function in both inflammasome-dependent and -independent manners. In this study, P2X7(−/−) mice, the pharmacological agonists ATP-magnesium salt (Mg-ATP; 100 mg/kg, EC(50) ≈ 1.32 mM) and benzoylbenzoyl-ATP (Bz-...

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書目詳細資料
發表在:FASEB J
Main Authors: Csóka, Balázs, Németh, Zoltán H., Törő, Gábor, Idzko, Marco, Zech, Andreas, Koscsó, Balázs, Spolarics, Zoltán, Antonioli, Luca, Cseri, Karolina, Erdélyi, Katalin, Pacher, Pál, Haskó, György
格式: Artigo
語言:Inglês
出版: Federation of American Societies for Experimental Biology 2015
主題:
Research Communication
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550379/
https://ncbi.nlm.nih.gov/pubmed/26060214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-272450
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