Rational Design of Highly Potent and Slow-Binding Cytochrome bc(1) Inhibitor as Fungicide by Computational Substitution Optimization

Hit to lead (H2L) optimization is a key step for drug and agrochemical discovery. A critical challenge for H2L optimization is the low efficiency due to the lack of predictive method with high accuracy. We described a new computational method called Computational Substitution Optimization (CSO) that...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Hao, Ge-Fei, Yang, Sheng-Gang, Huang, Wei, Wang, Le, Shen, Yan-Qing, Tu, Wen-Long, Li, Hui, Huang, Li-Shar, Wu, Jia-Wei, Berry, Edward A., Yang, Guang-Fu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549706/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13471
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