Whole genome sequence analysis links chromothripsis to EGFR, MDM2, MDM4, and CDK4 amplification in glioblastoma

BACKGROUND: Findings based on recent advances in next-generation sequence analysis suggest that, in some tumors, a single catastrophic event, termed chromothripsis, results in several simultaneous tumorigenic alterations. Previous studies have suggested that glioblastoma (GBM) may exhibit chromothri...

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Pubblicato in:Oncoscience
Autori principali: Furgason, John M., Koncar, Robert F., Michelhaugh, Sharon K., Sarkar, Fazlul H., Mittal, Sandeep, Sloan, Andrew E., Barnholtz-Sloan, Jill S., Bahassi, El Mustapha
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549359/
https://ncbi.nlm.nih.gov/pubmed/26328271
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