SERPINE2 Inhibits IL-1α-Induced MMP-13 Expression in Human Chondrocytes: Involvement of ERK/NF-κB/AP-1 Pathways

OBJECTIVES: Osteoarthritis (OA) is a chronic joint disease, characterized by a progressive loss of articular cartilage. During OA, proinflammatory cytokines, such as interleukin IL-1, induce the expression of matrix metalloproteinases (MMPs) in chondrocytes, contributing thus to the extracellular ma...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Santoro, Anna, Conde, Javier, Scotece, Morena, Abella, Vanessa, Lois, Ana, Lopez, Veronica, Pino, Jesus, Gomez, Rodolfo, Gomez-Reino, Juan J., Gualillo, Oreste
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549255/
https://ncbi.nlm.nih.gov/pubmed/26305372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135979
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