The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1

Progranulin (PGRN) is a recently identified adipokine that is supposed to have anti-inflammatory actions. The proinflammatory cytokine interleukin-1β (IL1β) stimulates several mediators of cartilage degradation. Toll like receptor-4 (TLR4) can bind to various damage-associated molecular patterns, le...

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Publicado no:Sci Rep
Main Authors: Abella, Vanessa, Scotece, Morena, Conde, Javier, López, Verónica, Pirozzi, Claudio, Pino, Jesús, Gómez, Rodolfo, Lago, Francisca, González-Gay, Miguel Ángel, Gualillo, Oreste
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745010/
https://ncbi.nlm.nih.gov/pubmed/26853108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20356
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