Xenopus pax6 mutants affect eye development and other organ systems, and have phenotypic similarities to human aniridia patients

Mutations in the Pax6 gene cause ocular defects in both vertebrate and invertebrate animal species, and the disease aniridia in humans. Despite extensive experimentation on this gene in multiple species, including humans, we still do not understand the earliest effects on development mediated by thi...

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Bibliographic Details
Published in:Dev Biol
Main Authors: Nakayama, Takuya, Fisher, Marilyn, Nakajima, Keisuke, Odeleye, Akinleye O., Zimmerman, Keith B., Fish, Margaret B., Yaoita, Yoshio, Chojnowski, Jena L., Lauderdale, James D., Netland, Peter A, Grainger, Robert M.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549229/
https://ncbi.nlm.nih.gov/pubmed/25724657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2015.02.012
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