Xenopus pax6 mutants affect eye development and other organ systems, and have phenotypic similarities to human aniridia patients

Mutations in the Pax6 gene cause ocular defects in both vertebrate and invertebrate animal species, and the disease aniridia in humans. Despite extensive experimentation on this gene in multiple species, including humans, we still do not understand the earliest effects on development mediated by thi...

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Veröffentlicht in:Dev Biol
Hauptverfasser: Nakayama, Takuya, Fisher, Marilyn, Nakajima, Keisuke, Odeleye, Akinleye O., Zimmerman, Keith B., Fish, Margaret B., Yaoita, Yoshio, Chojnowski, Jena L., Lauderdale, James D., Netland, Peter A, Grainger, Robert M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549229/
https://ncbi.nlm.nih.gov/pubmed/25724657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2015.02.012
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