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Acidosis Is a key regulator of osteoblast ecto‐nucleotidase pyrophosphatase/phosphodiesterase 1 (NPP1) expression and activity
Previous work has shown that acidosis prevents bone nodule formation by osteoblasts in vitro by inhibiting mineralisation of the collagenous matrix. The ratio of phosphate (P(i)) to pyrophosphate (PP(i)) in the bone microenvironment is a fundamental regulator of bone mineralisation. Both P(i) and PP...
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| Publicado no: | J Cell Physiol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4549203/ https://ncbi.nlm.nih.gov/pubmed/26033523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.25041 |
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