Thymoquinone inhibits TNF-α-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation

Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine produced by monocytes/macrophage that plays a pathological role in rheumatoid arthritis (RA). In this study, we investigate the effect of thymoquinone (TQ), a phytochemical found in Nigella sativa, in regulating TNF-α-induced RA synovial...

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Publicado en:Toxicol Appl Pharmacol
Autores principales: Umar, Sadiq, Hedaya, Omar, Singh, Anil K., Ahmed, Salahuddin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549173/
https://ncbi.nlm.nih.gov/pubmed/26134265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2015.06.017
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