Near Universal Detection of Alterations in CTNNB1 and Wnt Pathway Regulators in Desmoid-Type Fibromatosis by Whole-Exome Sequencing and Genomic Analysis

CTNNB1 mutations or APC abnormalities have been observed in ~85% of desmoids examined by Sanger sequencing and are associated with Wnt/β-catenin activation. We sought to identify molecular aberrations in ‘wild-type’ tumors (those without CTNNB1 or APC alteration) and to determine their prognostic re...

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Pubblicato in:Genes Chromosomes Cancer
Autori principali: Crago, Aimee M., Chmielecki, Juliann, Rosenberg, Mara, O’Connor, Rachael, Byrne, Caitlin, Wilder, Fatima G., Thorn, Katherine, Agius, Phaedra, Kuk, Deborah, Socci, Nicholas D., Qin, Li-Xuan, Meyerson, Matthew, Hameed, Meera, Singer, Samuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548882/
https://ncbi.nlm.nih.gov/pubmed/26171757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22272
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