Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory Phenotype

Vascular smooth muscle cells (VSMCs) that become senescent are both present within atherosclerotic plaques and thought to be important to the disease process. However, senescent VSMCs are generally considered to only contribute through inaction, with failure to proliferate resulting in VSMC- and col...

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Veröffentlicht in:Arterioscler Thromb Vasc Biol
Hauptverfasser: Gardner, Sarah E., Humphry, Melanie, Bennett, Martin R., Clarke, Murray C.H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Lippincott Williams & Wilkins 2015
Schlagworte:
Basic Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548545/
https://ncbi.nlm.nih.gov/pubmed/26139463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.305896
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