Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS

We have characterized the nuclear localization signal (NLS) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging. Crystallography and binding studies confirm the bipartite nature of the XRCC1 NLS interaction with Importin α (Impα) in which the major and minor...

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Pubblicato in:Sci Rep
Autori principali: Kirby, Thomas W., Gassman, Natalie R., Smith, Cassandra E., Pedersen, Lars C., Gabel, Scott A., Sobhany, Mack, Wilson, Samuel H., London, Robert E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548243/
https://ncbi.nlm.nih.gov/pubmed/26304019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13405
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