Characterization of Ku702–NLS as Bipartite Nuclear Localization Sequence for Non-Viral Gene Delivery

Several barriers have to be overcome in order to achieve gene expression in target cells, e.g. cellular uptake, endosomal release and translocation to the nucleus. Nuclear localization sequences (NLS) enhance gene delivery by increasing the uptake of plasmid DNA (pDNA) to the nucleus. So far, only m...

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Detalhes bibliográficos
Main Authors: Matschke, Johannes, Bohla, Alexander, Maucksch, Christof, Mittal, Rashmi, Rudolph, Carsten, Rosenecker, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275586/
https://ncbi.nlm.nih.gov/pubmed/22347357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024615
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