The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage

Spermatogonial stem cells (SSCs) undergo self-renewal divisions to provide the foundation for spermatogenesis. Although Rb1 deficiency is reportedly essential for SSC self-renewal, its mechanism has remained unknown. Here we report that Rb1 is critical for cell cycle progression and protection of SS...

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Udgivet i:J Reprod Dev
Main Authors: TANAKA, Takashi, KANATSU-SHINOHARA, Mito, SHINOHARA, Takashi
Format: Artigo
Sprog:Inglês
Udgivet: The Society for Reproduction and Development 2015
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547988/
https://ncbi.nlm.nih.gov/pubmed/25959802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1262/jrd.2015-027
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