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The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage
Spermatogonial stem cells (SSCs) undergo self-renewal divisions to provide the foundation for spermatogenesis. Although Rb1 deficiency is reportedly essential for SSC self-renewal, its mechanism has remained unknown. Here we report that Rb1 is critical for cell cycle progression and protection of SS...
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| Publicado no: | J Reprod Dev |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Society for Reproduction and Development
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4547988/ https://ncbi.nlm.nih.gov/pubmed/25959802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1262/jrd.2015-027 |
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