DISRUPTION OF CYTOCHROME C HEME COORDINATION IS RESPONSIBLE FOR MITOCHONDRIAL INJURY DURING ISCHEMIA

BACKGROUND: It was recently suggested that electron flow into cyt c, coupled with ROS generation, oxidizes cyt c Met(80) to Met(80) sulfoxide (Met-O) in isolated hearts after ischemia-reperfusion, and converts cyt c to a peroxidase. We hypothesize that ischemia disrupts Met(80)-Fe ligation of cyt c,...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Birk, Alexander V., Chao, Wesley M., Liu, Shaoyi, Soong, Yi, Szeto, Hazel H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547887/
https://ncbi.nlm.nih.gov/pubmed/26071084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2015.06.006
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