Single-Cell Genetic Analysis Using Automated Microfluidics to Resolve Somatic Mosaicism

Somatic mosaicism occurs throughout normal development and contributes to numerous disease etiologies, including tumorigenesis and neurological disorders. Intratumor genetic heterogeneity is inherent to many cancers, creating challenges for effective treatments. Unfortunately, analysis of bulk DNA m...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Szulwach, Keith E., Chen, Peilin, Wang, Xiaohui, Wang, Jing, Weaver, Lesley S., Gonzales, Michael L., Sun, Gang, Unger, Marc A., Ramakrishnan, Ramesh
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547741/
https://ncbi.nlm.nih.gov/pubmed/26302375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135007
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