Single-Cell Genetic Analysis Using Automated Microfluidics to Resolve Somatic Mosaicism

Somatic mosaicism occurs throughout normal development and contributes to numerous disease etiologies, including tumorigenesis and neurological disorders. Intratumor genetic heterogeneity is inherent to many cancers, creating challenges for effective treatments. Unfortunately, analysis of bulk DNA m...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Szulwach, Keith E., Chen, Peilin, Wang, Xiaohui, Wang, Jing, Weaver, Lesley S., Gonzales, Michael L., Sun, Gang, Unger, Marc A., Ramakrishnan, Ramesh
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547741/
https://ncbi.nlm.nih.gov/pubmed/26302375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135007
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