Structure-activity relationships of substituted 1H-indole-2-carboxamides as CB1 receptor allosteric modulators

A series of substituted 1H-indole-2-carboxamides structurally related to compounds Org27569 (1), Org29647 (2) and Org27759 (3) were synthesized and evaluated for CB1 allosteric modulating activity in calcium mobilization assays. Structure-activity relationship studies showed that the modulation pote...

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Détails bibliographiques
Publié dans:Bioorg Med Chem
Auteurs principaux: Nguyen, Thuy, German, Nadezhda, Decker, Ann M., Li, Jun-Xu, Wiley, Jenny L., Thomas, Brian F., Kenakin, Terry P., Zhang, Yanan
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547606/
https://ncbi.nlm.nih.gov/pubmed/25797163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.02.058
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