Summarizing polygenic risks for complex diseases in a clinical whole genome report

PURPOSE: Disease-causing mutations and pharmacogenomic variants are of primary interest for clinical whole-genome sequencing. However, estimating genetic liability for common complex diseases using established risk alleles might one day prove clinically useful. METHODS: We compared polygenic scoring...

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Veröffentlicht in:Genet Med
Hauptverfasser: Kong, Sek Won, Lee, In-Hee, Leschiner, Ignaty, Krier, Joel, Kraft, Peter, Rehm, Heidi L., Green, Robert C., Kohane, Isaac S., MacRae, Calum A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547452/
https://ncbi.nlm.nih.gov/pubmed/25341114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gim.2014.143
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