RabGDIα is a negative regulator of interferon-γ–inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii

IFN-γ orchestrates cell-autonomous host defense against various intracellular vacuolar pathogens. IFN-γ–inducible GTPases, such as p47 immunity-related GTPases (IRGs) and p65 guanylate-binding proteins (GBPs), are recruited to pathogen-containing vacuoles, which is important for disruption of the va...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Ohshima, Jun, Sasai, Miwa, Liu, Jianfa, Yamashita, Kazuo, Ma, Ji Su, Lee, Youngae, Bando, Hironori, Howard, Jonathan C., Ebisu, Shigeyuki, Hayashi, Mikako, Takeda, Kiyoshi, Standley, Daron M., Frickel, Eva-Maria, Yamamoto, Masahiro
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547277/
https://ncbi.nlm.nih.gov/pubmed/26240314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510031112
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