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Local axonal protection by WldS as revealed by conditional regulation of protein stability

The expression of the mutant Wallerian degeneration slow (WldS) protein significantly delays axonal degeneration from various nerve injuries and in multiple species; however, the mechanism for its axonal protective property remains unclear. Although WldS is localized predominantly in the nucleus, it...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Jack T., Medress, Zachary A., Vargas, Mauricio E., Barres, Ben A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547231/
https://ncbi.nlm.nih.gov/pubmed/26209654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508337112
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