Synaptobrevin Transmembrane Domain Dimerization Studied by Multiscale Molecular Dynamics Simulations

Synaptic vesicle fusion requires assembly of the SNARE complex composed of SNAP-25, syntaxin-1, and synaptobrevin-2 (sybII) proteins. The SNARE proteins found in vesicle membranes have previously been shown to dimerize via transmembrane (TM) domain interactions. While syntaxin homodimerization is su...

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Udgivet i:Biophys J
Main Authors: Han, Jing, Pluhackova, Kristyna, Wassenaar, Tsjerk A., Böckmann, Rainer A.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2015
Fag:
Membranes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547142/
https://ncbi.nlm.nih.gov/pubmed/26287628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.049
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