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Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover.

The rat M1 muscarinic receptor gene was cloned and expressed in a rat cell line lacking endogenous muscarinic receptors. Assignment of the cloned receptors to the M1 class was pharmacologically confirmed by their high affinity for the M1-selective muscarinic antagonist pirenzepine and low affinity f...

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Publicat a:EMBO J
Autors principals: Stein, R, Pinkas-Kramarski, R, Sokolovsky, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1988
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC454689/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2846274/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1988.tb03167.x
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