Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover.
The rat M1 muscarinic receptor gene was cloned and expressed in a rat cell line lacking endogenous muscarinic receptors. Assignment of the cloned receptors to the M1 class was pharmacologically confirmed by their high affinity for the M1-selective muscarinic antagonist pirenzepine and low affinity f...
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| Publicado no: | EMBO J |
|---|---|
| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
1988
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC454689/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2846274/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1988.tb03167.x |
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