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FBG1 Is the Final Arbitrator of A1AT-Z Degradation
Alpha-1 antitrypsin deficiency is the leading cause of childhood liver failure and one of the most common lethal genetic diseases. The disease-causing mutant A1AT-Z fails to fold correctly and accumulates in the endoplasmic reticulum (ER) of the liver, resulting in hepatic fibrosis and hepatocellula...
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| Publicado en: | PLoS One |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4546667/ https://ncbi.nlm.nih.gov/pubmed/26295339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135591 |
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