Rare coding mutations identified by sequencing of Alzheimer disease genome‐wide association studies loci

OBJECTIVE: To detect rare coding variants underlying loci detected by genome‐wide association studies (GWAS) of late onset Alzheimer disease (LOAD). METHODS: We conducted targeted sequencing of ABCA7, BIN1, CD2AP, CLU, CR1, EPHA1, MS4A4A/MS4A6A, and PICALM in 3 independent LOAD cohorts: 176 patients...

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Detalhes bibliográficos
Publicado no:Ann Neurol
Main Authors: Vardarajan, Badri N., Ghani, Mahdi, Kahn, Amanda, Sheikh, Stephanie, Sato, Christine, Barral, Sandra, Lee, Joseph H., Cheng, Rong, Reitz, Christiane, Lantigua, Rafael, Reyes‐Dumeyer, Dolly, Medrano, Martin, Jimenez‐Velazquez, Ivonne Z., Rogaeva, Ekaterina, St George‐Hyslop, Peter, Mayeux, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546546/
https://ncbi.nlm.nih.gov/pubmed/26101835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24466
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