Rare coding mutations identified by sequencing of Alzheimer disease genome‐wide association studies loci

OBJECTIVE: To detect rare coding variants underlying loci detected by genome‐wide association studies (GWAS) of late onset Alzheimer disease (LOAD). METHODS: We conducted targeted sequencing of ABCA7, BIN1, CD2AP, CLU, CR1, EPHA1, MS4A4A/MS4A6A, and PICALM in 3 independent LOAD cohorts: 176 patients...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Ann Neurol
Autori principali: Vardarajan, Badri N., Ghani, Mahdi, Kahn, Amanda, Sheikh, Stephanie, Sato, Christine, Barral, Sandra, Lee, Joseph H., Cheng, Rong, Reitz, Christiane, Lantigua, Rafael, Reyes‐Dumeyer, Dolly, Medrano, Martin, Jimenez‐Velazquez, Ivonne Z., Rogaeva, Ekaterina, St George‐Hyslop, Peter, Mayeux, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546546/
https://ncbi.nlm.nih.gov/pubmed/26101835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24466
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi