The indirect NMDAR inhibitor flupirtine induces sustained post-ischemic recovery, neuroprotection and angioneurogenesis

N-methyl-D-aspartate receptor (NMDAR) activation induces excitotoxicity, contributing to post-stroke brain injury. Hitherto, NMDAR deactivation failed in clinical trials due to insufficient pre-clinical study designs and drug toxicity. Flupirtine is an indirect NMDAR antagonist being used as analges...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Jaeger, Hanna M., Pehlke, Jens R., Kaltwasser, Britta, Kilic, Ertugrul, Bähr, Mathias, Hermann, Dirk M., Doeppner, Thorsten R.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper: Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546449/
https://ncbi.nlm.nih.gov/pubmed/26050199
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