Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions

INTRODUCTION: Metformin is proposed as adjuvant therapy in cancer treatment because of its ability to limit cancer incidence by negatively modulating the PI3K/AKT/mTOR pathway. In vitro, in addition to inhibiting cancer cell proliferation, metformin can also induce apoptosis. The molecular mechanism...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Silvestri, Alessandra, Palumbo, Francesco, Rasi, Ignazio, Posca, Daniela, Pavlidou, Theodora, Paoluzi, Serena, Castagnoli, Luisa, Cesareni, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546379/
https://ncbi.nlm.nih.gov/pubmed/26291325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136250
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