INTRANUCLEAR MATRIX METALLOPROTEINASES PROMOTE DNA DAMAGE AND APOPTOSIS INDUCED BY OXYGEN–GLUCOSE DEPRIVATION IN NEURONS

Degradation of the extracellular matrix by elevated matrix metalloproteinase (MMP) activity following ischemia/reperfusion is implicated in blood–brain barrier disruption and neuronal death. In contrast to their characterized extracellular roles, we previously reported that elevated intranuclear MMP...

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Detalhes bibliográficos
Publicado no:Neuroscience
Main Authors: Hill, J. W., Poddar, R., Thompson, J. F., Rosenberg, G. A., Yang, Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546359/
https://ncbi.nlm.nih.gov/pubmed/22710064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2012.06.019
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