Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion

HECT, UBA and WWE domain-containing 1 (Huwe1), an E3 ubiquitin ligase involved in the ubiquitin-proteasome system, is widely expressed in brain tissue. Huwe1 is involved in the turnover of numerous substrates, including p53, Mcl-1, Cdc6 and N-myc, thereby playing a critical role in apoptosis and neu...

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Bibliographische Detailangaben
Veröffentlicht in:Neural Regen Res
Hauptverfasser: He, Guo-Qian, Xu, Wen-Ming, Liao, Hui-Juan, Jiang, Chuan, Li, Chang-Qing, Zhang, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wolters Kluwer - Medknow 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676871/
https://ncbi.nlm.nih.gov/pubmed/31290456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1673-5374.259620
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