Dynamics of gene silencing during X inactivation using allele-specific RNA-seq

BACKGROUND: During early embryonic development, one of the two X chromosomes in mammalian female cells is inactivated to compensate for a potential imbalance in transcript levels with male cells, which contain a single X chromosome. Here, we use mouse female embryonic stem cells (ESCs) with non-rand...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Marks, Hendrik, Kerstens, Hindrik H. D., Barakat, Tahsin Stefan, Splinter, Erik, Dirks, René A. M., van Mierlo, Guido, Joshi, Onkar, Wang, Shuang-Yin, Babak, Tomas, Albers, Cornelis A., Kalkan, Tüzer, Smith, Austin, Jouneau, Alice, de Laat, Wouter, Gribnau, Joost, Stunnenberg, Hendrik G.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546214/
https://ncbi.nlm.nih.gov/pubmed/26235224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0698-x
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