Abatacept decreases disease activity in a absence of CD4(+) T cells in a collagen-induced arthritis model

INTRODUCTION: Abatacept is a fusion protein of human cytotoxic T-lymphocyte–associated protein (CTLA)-4 and the Fc portion of human immunoglobulin G1 (IgG1). It is believed to be effective in the treatment of rheumatoid arthritis by inhibiting costimulation of T cells via blocking CD28–B7 interactio...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Jansen, Diahann TSL, el Bannoudi, Hanane, Arens, Ramon, Habets, Kim LL, Hameetman, Marjolijn, Huizinga, Tom WJ, Stoop, Jeroen N., Toes, René EM
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545927/
https://ncbi.nlm.nih.gov/pubmed/26290328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0731-1
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