Fluorescence Biomembrane Force Probe: Concurrent Quantitation of Receptor-ligand Kinetics and Binding-induced Intracellular Signaling on a Single Cell

Membrane receptor-ligand interactions mediate many cellular functions. Binding kinetics and downstream signaling triggered by these molecular interactions are likely affected by the mechanical environment in which binding and signaling take place. A recent study demonstrated that mechanical force ca...

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Detalhes bibliográficos
Publicado no:J Vis Exp
Main Authors: Chen, Yunfeng, Liu, Baoyu, Ju, Lining, Hong, Jinsung, Ji, Qinghua, Chen, Wei, Zhu, Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: MyJove Corporation 2015
Assuntos:
Bioengineering
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4544851/
https://ncbi.nlm.nih.gov/pubmed/26274371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/52975
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