Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site

Activated retina-specific T cells that have acquired the ability to break through the blood-retinal barrier are thought to be causally involved in autoimmune uveitis, a major cause of human blindness. It is unclear where these autoreactive T cells first become activated, given that their cognate ant...

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Veröffentlicht in:Immunity
Hauptverfasser: Horai, Reiko, Zárate-Bladés, Carlos R., Dillenburg-Pilla, Patricia, Chen, Jun, Kielczewski, Jennifer L., Silver, Phyllis B., Jittayasothorn, Yingyos, Chan, Chi-Chao, Yamane, Hidehiro, Honda, Kenya, Caspi, Rachel R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4544742/
https://ncbi.nlm.nih.gov/pubmed/26287682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.07.014
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