Antibody engineering for the analysis of affinity maturation of an anti-hapten response.

The influence of structural variation, previously observed in a panel of V186.2 VH/V lambda 1-expressing anti-NP antibodies from the secondary response, on the affinity of these antibodies was examined by site-specific mutagenesis and recombinant antibody construction. A tryptophan----leucine exchan...

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Bibliographic Details
Main Authors: Allen, D, Simon, T, Sablitzky, F, Rajewsky, K, Cumano, A
Format: Artigo
Language:Inglês
Published: 1988
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC454473/
https://ncbi.nlm.nih.gov/pubmed/3138111
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