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Antibody engineering for the analysis of affinity maturation of an anti-hapten response.
The influence of structural variation, previously observed in a panel of V186.2 VH/V lambda 1-expressing anti-NP antibodies from the secondary response, on the affinity of these antibodies was examined by site-specific mutagenesis and recombinant antibody construction. A tryptophan----leucine exchan...
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| 出版年: | EMBO J |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
1988
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC454473/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3138111/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1988.tb03038.x |
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