Pharmacological WNT Inhibition Reduces Proliferation, Survival and Clonogenicity of Glioblastoma Cells

Wingless (WNT) signaling has been shown to be an important pathway in gliomagenesis and in the growth of stem-like glioma cells. Using immunohistochemistry to assess translocation of β-catenin protein, we identified intranuclear staining, which suggest WNT pathway activation, in 8 of 43 (19%) adult...

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Publié dans:J Neuropathol Exp Neurol
Auteurs principaux: Kahlert, Ulf D., Suwala, Abigail K., Koch, Katharina, Natsumeda, Manabu, Orr, Brent A., Hayashi, Masanori, Maciaczyk, Jarek, Eberhart, Charles G.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4544656/
https://ncbi.nlm.nih.gov/pubmed/26222502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0000000000000227
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