Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart.

The effects of the oxidant species peroxynitrite (ONOO-) on coronary perfusion pressure and vasodilatation elicited by acetylcholine, isoproterenol, and S-nitroso-N-acetyl-DL-penicillamine were investigated in the isolated perfused rat heart. ONOO- (0.3-1000 microM) caused a concentration-dependent...

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Bibliographic Details
Main Authors: Villa, L M, Salas, E, Darley-Usmar, V M, Radomski, M W, Moncada, S
Format: Artigo
Language:Inglês
Published: 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC45442/
https://ncbi.nlm.nih.gov/pubmed/7809045
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