Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children

There is increasing evidence from genome-wide association studies for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children, yet the effects of protein-coding variants on ALL risk have not been systematically evaluated. Here we show a missense variant...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Xu, Heng, Zhang, Hui, Yang, Wenjian, Yadav, Rachita, Morrison, Alanna C., Qian, Maoxiang, Devidas, Meenakshi, Liu, Yu, Perez-Andreu, Virginia, Zhao, Xujie, Gastier-Foster, Julie M., Lupo, Philip J., Neale, Geoff, Raetz, Elizabeth, Larsen, Eric, Bowman, W. Paul, Carroll, William L., Winick, Naomi, Williams, Richard, Hansen, Torben, Holm, Jens-Christian, Mardis, Elaine, Fulton, Robert, Pui, Ching-Hon, Zhang, Jinghui, Mullighan, Charles G., Evans, William E., Hunger, Stephen P., Gupta, Ramneek, Schmiegelow, Kjeld, Loh, Mignon L., Relling, Mary V., Yang, Jun J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4544058/
https://ncbi.nlm.nih.gov/pubmed/26104880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8553
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