Rheostatic Regulation of the SERCA/Phospholamban Membrane Protein Complex Using Non-Coding RNA and Single-Stranded DNA oligonucleotides

The membrane protein complex between sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) and phospholamban (PLN) is a prime therapeutic target for reversing cardiac contractile dysfunctions caused by calcium mishandling. So far, however, efforts to develop drugs specific for this protein complex have...

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Vydáno v:Sci Rep
Hlavní autoři: Soller, Kailey J., Verardi, Raffaello, Jing, Meng, Abrol, Neha, Yang, Jing, Walsh, Naomi, Vostrikov, Vitaly V., Robia, Seth L., Bowser, Michael T., Veglia, Gianluigi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543939/
https://ncbi.nlm.nih.gov/pubmed/26292938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13000
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