Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions

Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and counterregulator of glucocorticoids, is a potential therapeutic target. MIF is markedly different from other cytokines because it is constitutively expressed, stored in the cytoplasm, and present in the circulation of healt...

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Publicado en:J Immunol
Autores principales: Thiele, Michael, Kerschbaumer, Randolf J., Tam, Frederick W. K., Völkel, Dirk, Douillard, Patrice, Schinagl, Alexander, Kühnel, Harald, Smith, Jennifer, McDaid, John P., Bhangal, Gurjeet, Yu, Mei-Ching, Pusey, Charles D., Cook, H. Terence, Kovarik, Josef, Magelky, Erica, Bhan, Atul, Rieger, Manfred, Mudde, Geert C., Ehrlich, Hartmut, Jilma, Bernd, Tilg, Herbert, Moschen, Alexander, Terhorst, Cox, Scheiflinger, Friedrich
Formato: Artigo
Lenguaje:Inglês
Publicado: AAI 2015
Materias:
Innate Immunity and Inflammation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543907/
https://ncbi.nlm.nih.gov/pubmed/26209628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500572
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