Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the β-Sheet Structure of MIF

The macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that recently emerged as an attractive therapeutic target for a variety of diseases. A diverse panel of fully human anti-MIF antibodies was generated by selection from a phage display library and extensively analyzed in v...

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Hauptverfasser: Kerschbaumer, Randolf J., Rieger, Manfred, Völkel, Dirk, Le Roy, Didier, Roger, Thierry, Garbaraviciene, Jurate, Boehncke, Wolf-Henning, Müllberg, Jürgen, Hoet, Rene M., Wood, Clive R., Antoine, Gerhard, Thiele, Michael, Savidis-Dacho, Helga, Dockal, Michael, Ehrlich, Hartmut, Calandra, Thierry, Scheiflinger, Friedrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293543/
https://ncbi.nlm.nih.gov/pubmed/22238348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.329664
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