H5N1 Whole-Virus Vaccine Induces Neutralizing Antibodies in Humans Which Are Protective in a Mouse Passive Transfer Model

BACKGROUND: Vero cell culture-derived whole-virus H5N1 vaccines have been extensively tested in clinical trials and consistently demonstrated to be safe and immunogenic; however, clinical efficacy is difficult to evaluate in the absence of wide-spread human disease. A lethal mouse model has been uti...

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Hauptverfasser: Howard, M. Keith, Sabarth, Nicolas, Savidis-Dacho, Helga, Portsmouth, Daniel, Kistner, Otfried, Kreil, Thomas R., Ehrlich, Hartmut J., Barrett, P. Noel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158096/
https://ncbi.nlm.nih.gov/pubmed/21876771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023791
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