Immunogenicity and Protective Efficacy of a Vero Cell Culture-Derived Whole-Virus H7N9 Vaccine in Mice and Guinea Pigs

BACKGROUND: A novel avian H7N9 virus with a high case fatality rate in humans emerged in China in 2013. We evaluated the immunogenicity and protective efficacy of a candidate Vero cell culture-derived whole-virus H7N9 vaccine in small animal models. METHODS: Antibody responses induced in immunized D...

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Veröffentlicht in:PLoS One
Hauptverfasser: Wodal, Walter, Schwendinger, Michael G., Savidis-Dacho, Helga, Crowe, Brian A., Hohenadl, Christine, Fritz, Richard, Brühl, Peter, Portsmouth, Daniel, Karner-Pichl, Anita, Balta, Dalida, Grillberger, Leopold, Kistner, Otfried, Barrett, P. Noel, Howard, M. Keith
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342221/
https://ncbi.nlm.nih.gov/pubmed/25719901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113963
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