A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction.

The EGF-receptor (EGF-R) is a transmembrane glycoprotein with intrinsic protein tyrosine kinase (TK) activity. To explore the importance of the receptor TK in the action of EGF, we have used transfected NIH-3T3 cells expressing either the normal human EGF-R or a receptor mutated at Lys721, a key res...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Moolenaar, W H, Bierman, A J, Tilly, B C, Verlaan, I, Defize, L H, Honegger, A M, Ullrich, A, Schlessinger, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1988
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC454377/
https://ncbi.nlm.nih.gov/pubmed/3260862
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados