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The Interplay between Wnt Mediated Expansion and Negative Regulation of Growth Promotes Robust Intestinal Crypt Structure and Homeostasis

The epithelium of the small intestinal crypt, which has a vital role in protecting the underlying tissue from the harsh intestinal environment, is completely renewed every 4–5 days by a small pool of stem cells at the base of each crypt. How is this renewal controlled and homeostasis maintained, par...

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Pubblicato in:PLoS Comput Biol
Autori principali: Du, Huijing, Nie, Qing, Holmes, William R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543550/
https://ncbi.nlm.nih.gov/pubmed/26288152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004285
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