Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation

BACKGROUND & AIMS: Liver fibrosis, an important health concern associated to chronic liver injury that provides a permissive environment for cancer development, is characterized by accumulation of extracellular matrix components mainly derived from activated hepatic stellate cells (HSCs). Axl, a...

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Gepubliceerd in:J Hepatol
Hoofdauteurs: Bárcena, Cristina, Stefanovic, Milica, Tutusaus, Anna, Joannas, Leonel, Menéndez, Anghara, García-Ruiz, Carmen, Sancho-Bru, Pau, Marí, Montserrat, Caballeria, Joan, Rothlin, Carla V., Fernández-Checa, José C., de Frutos, Pablo García, Morales, Albert
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543529/
https://ncbi.nlm.nih.gov/pubmed/25908269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.04.013
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