ANTIOXIDANTS PROTECT CALSEQUESTRIN-1 KNOCKOUT MICE FROM HALOTHANE- AND HEAT-INDUCED SUDDEN DEATH

BACKGROUND: Mice lacking calsequestrin-1 (CASQ1-null), a Ca(2+) binding protein that modulates the activity of Ca(2+) release in skeletal muscle, exhibit lethal hypermetabolic episodes that resemble malignant hyperthermia (MH) in humans when exposed to halothane or heat stress. METHODS: As oxidative...

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Detaylı Bibliyografya
Yayımlandı:Anesthesiology
Asıl Yazarlar: Michelucci, Antonio, Paolini, Cecilia, Canato, Marta, Wei-Lapierre, Lan, Pietrangelo, Laura, De Marco, Alessandro, Reggiani, Carlo, Dirksen, Robert T., Protasi, Feliciano
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543432/
https://ncbi.nlm.nih.gov/pubmed/26132720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000748
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