Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIII

Binding to the von Willebrand factor (VWF) D′D3 domains protects factor VIII (FVIII) from rapid clearance. We performed single-particle electron microscopy (EM) analysis of negatively stained specimens to examine the architecture of D′D3 alone and in complex with FVIII. The D′D3 dimer ([D′D3](2)) co...

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Publicat a:Blood
Autors principals: Yee, Andrew, Oleskie, Austin N., Dosey, Anne M., Kretz, Colin A., Gildersleeve, Robert D., Dutta, Somnath, Su, Min, Ginsburg, David, Skiniotis, Georgios
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Plenary Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543228/
https://ncbi.nlm.nih.gov/pubmed/26065653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-641696
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